GM Crop Database

Database Product Description

TC1507 x MON810 x MIR162 (DAS-Ø15Ø7-1 x MON-ØØ81Ø-6 x SYN-IR162-4)
Host Organism
Zea mays (Maize)
Trait

Herbicide Tolerance, Insect Resistance

Trait Introduction
Traditional plant breeding and selection
Proposed Use

Production for human consumption and livestock feed.

Product Developer
DuPont Pioneer

Summary of Regulatory Approvals

Country Food Feed Environment Notes
Argentina 2016 2016 2016
Brazil 2015 2015 2015
Colombia 2016
Japan 2013 2013 2014
Korea 2015 2015
Mexico 2015 2015
Taiwan 2015
United States 2013

Introduction Expand

TC1507 x MON810 x MIR162 is a stacked event variety expressing three Bt proteins to confer resistance to lepidopteran insects (Cry1Ab, Cry1F, Vip3A) and one protein (PAT protein) conferring tolerance to the herbicide glufosinate ammonium.

Summary of Introduced Genetic Elements Expand

Code Name Type Promoter, other Terminator Copies Form
cry1Ab Cry1Ab delta-endotoxin (Btk HD-1) IR

Enhanced CaMV 35S, from Cauliflower mosaic virus; maize HSP70 intron

None. Lost through 3’ truncation during integration

1

Truncated

pmi mannose-6-phosphate isomerase SM

ZmUbilnt (Zea mays poly-ubiquitin gene promoter and first intron)

Agrobacterium tumefaciens nopaline synthase (nos) 3”-untranslated region

1
vip3Aa20 vegetative insecticidal protein IR

ZmUbilnt (Zea mays polyubiquitin gene promoter and first intron)

CaMV 35S 3’ polyadenylation signal

1

Native

pat Phosphinothricin N-acetyltransferase HT

CaMV35 (Cauliflower mosaic virus)

CaMV35 3’polyadenylation signal (Cauliflower mosaic virus)

1 functional
cry1Fa2 Cry1F delta-endotoxin IR

Ubiquitin (ubi) ZM (Zea mays) promoter and the first exon and intron

3’ polyadenylation signal from ORF25 (Agrobacterium tumefaciens)

1 functional; 1-2 partial

Altered coding sequence for optimal expression in plant cells

Characteristics of Zea mays (Maize) Expand

Center of Origin Reproduction Toxins Allergenicity

Mesoamerican region, now Mexico and Central America

Cross-pollination via wind-borne pollen is limited, pollen viability is about 30 minutes. Hybridization reported with teosinte species and rarely with members of the genus Tripsacum.

No endogenous toxins or significant levels of antinutritional factors.

Although some reported cases of maize allergy, protein(s) responsible have not been identified.

Donor Organism Characteristics Expand

Latin Name Gene Pathogenicity
Bacillus thuringiensis subsp. kurstaki cry1Ac

Although target insects are susceptible to oral doses of Bt proteins, there is no evidence of toxic effects in laboratory mammals or bird given up to 10 µg protein / g body wt. There are no significant mammalian toxins or allergens associated with the host organism.

Escherichia coli (K-12) hyg

Escherichia coli is one of a number of microorganisms which are normal inhabitants of the colons of virtually all warm-blooded mammals. Ecoli belongs to the taxonomic family known asEnterobacteriaceae, which is one of the best-defined groups of bacteria. The strain Ecoli K-12 is a debilitated strain which does not normally colonize the human intestine. It has also been shown to survive poorly in the environment, has a history of safe commercial use, and is not known to have adverse effects on microorganisms or plants. 

Bacillus thuringiensis strain AB88 5AT

While target lepidopteran insects are susceptible to oral doses of VIP proteins, there is no evidence of toxic effects in laboratory mammals, in birds, and in non-target arthropods, including beneficial insects.

Streptomyces viridochromogenes pat

S. viridochromogenes is ubiquitous in the soil. It exhibits very slight antimicrobial activity, is inhibited by streptomycin, and there have been no reports of adverse affects on humans, animals, or plants.

Bacillus thuringiensis var. aizawai cry1F While target insects are susceptible to oral doses of Bt proteins, no evidence of toxic effects in laboratory mammals or birds.

Modification Method Expand

Coming soon. 

Characteristics of the Modification Expand

Coming soon. 

Environmental Safety Considerations Expand

Coming soon. 

Food and/or Feed Safety Considerations Expand

Coming soon. 

Links to Further Information Expand

Japan, Ministry of Agriculture, Forestry and Fisheries

This record was last modified on Friday, August 11, 2017