Database Product Description
- Host Organism
- Zea mays (Maize)
- Trade Name
- Herculex® XTRA
Herbicide tolerant, glufosinate ammonium; Insect resistant, Coleoptera; Insect resistant, Lepidoptera.
- Trait Introduction
- Traditional plant breeding and selection
- Proposed Use
Production for human consumption and livestock feed.
- Product Developer
- DOW AgroSciences LLC and Pioneer Hi-Bred International Inc.
Summary of Regulatory Approvals
Summary of Introduced Genetic Elements Expand
Characteristics of Zea mays (Maize) Expand
Donor Organism Characteristics Expand
Modification Method Expand
Characteristics of the Modification Expand
Environmental Safety Considerations Expand
Food and/or Feed Safety Considerations Expand
TC1507 X DAS-59122-7(OECD identifier: DAS-Ø15Ø7-1 X DAS-59122-7) maize is an F1 hybrid resulting from the hybridization of the lepidopteran-resistant inbred maize TC1507 with the coleopteran-resistant maize inbred DAS-59122-7 and marketed as Herculex® XTRA. This stacked maize hybrid is a product of traditional plant breeding, and therefore is not automatically subject to regulation in all jurisdictions as are transgenic plants resulting from recombinant DNA technologies. Certain jurisdictions may request notification in advance of the release of a stacked hybrid, or may request information to conduct an environmental and food safety assessment. Examples of jurisdictions that require either notification or information about stacked hybrids prior to their release into the environment, and for use in human food and livestock feed are Japan and Korea.
The stacked hybrid TC1507 X DAS-59122-7 expresses four novel proteins: the delta-endotoxin Cry1F which confers resistance to the European Corn Borer and other lepidopterans, Cry34Ab1 and Cry35Ab1, which are also delta-endotoxins in this case insecticidal to coleopterans such as the Corn Rootworm, and the PAT protein which confers tolerance to the herbicide glufosinate ammonium. The Cry1F protein is produced by the cry1F gene and PAT is produced by the pat gene, both from TC1507. The Cry34Ab1 and Cry35Ab1 insecticidal proteins are produced by the cry34Ab1 and cry35Ab1 genes from DAS-59122-7, which also contains a copy of the pat gene. The novel traits of each parental line have been combined, through traditional plant breeding, to produce this new hybrid. For a full description of each parental line please refer to the individual product descriptions in the crop database for TC1507 and DAS-59122-7.
The inserted genes and their gene products have a history of safe use, and have undergone review and approval by several regulatory agencies. No interactions among the gene products or negative synergistic effects are expected in the stacked hybrid. The Cry1F, Cry34Ab1 and Cry35Ab1 proteins are not enzymes and therefore do not affect plant metabolism. The PAT enzyme has a high substrate affinity for L-Phosphinothricin, the active ingredient in glufosinate ammonium. These proteins are not expected to interact within, nor affect the metabolism of the stacked hybrid.
Links to Further Information Expand
This record was last modified on Tuesday, November 3, 2015