GM Crop Database

Database Product Description

NF872 (OKA-NBØØ3-1)
Host Organism
Malus ssp. (Apple)
Product Quality
Trait Introduction
Agrobacterium tumefaciens-mediated plant transformation.
Proposed Use

Production for human consumption.

Product Developer
Okanagan Specialty Fruits Inc.

Summary of Regulatory Approvals

Country Food Feed Environment Notes
United States 2016 2016 2016

Introduction Expand

Coming soon.

Summary of Introduced Genetic Elements Expand

Code Name Type Promoter, other Terminator Copies Form
PGAS PPO suppression transgene PQ




PGAS consists of 394 to 457 bp regions of four apple PPO genes (PPO2, GPO3, APO5, and pSR7) in tandem that upon transcription is designed to suppress the expression of these four members of the apple PPO gene family (Armstrong and Lane, 2009; pp. 31-36 in OSF, 2012). 

nptII neomycin phosphotransferase II SM




nptII, neomycin phosphotransferase type II gene from E. coli Tn5 (Rothstein et al., 1981; Bevan, 1984)

Characteristics of Malus ssp. (Apple) Expand

Center of Origin Reproduction Toxins Allergenicity

Mountainous regions in Central Asia, notably the western foothills of the Tian Shan Mountains of Kazakhstan and nearby areas with similar ecology.

Pollination is carried out by insects, primarily cultivated or wild honeybees or other insect pollinators such as bumblebees, osmia bees and other species.

Apples and apple trees are not known to contain toxic substances. 

Apples and apple trees are not known to contain allergenic substances. 

Donor Organism Characteristics Expand

Latin Name Gene Pathogenicity
Malus domestica PGAS

Apple is not known to have pathogenic characteristics.

Escherichia coli (K-12) hyg

Escherichia coli is one of a number of microorganisms which are normal inhabitants of the colons of virtually all warm-blooded mammals. Ecoli belongs to the taxonomic family known asEnterobacteriaceae, which is one of the best-defined groups of bacteria. The strain Ecoli K-12 is a debilitated strain which does not normally colonize the human intestine. It has also been shown to survive poorly in the environment, has a history of safe commercial use, and is not known to have adverse effects on microorganisms or plants. 

Modification Method Expand

Coming soon.

Characteristics of the Modification Expand

Coming soon.

Environmental Safety Considerations Expand

Coming soon.

Food and/or Feed Safety Considerations Expand

Coming soon.

Links to Further Information Expand

This record was last modified on Wednesday, January 4, 2017