GM Crop Database

Database Product Description

MON87708 (MON-877Ø8-9)
Host Organism
Glycine max (Soybean)
Trait
Herbicide Tolerance
Trait Introduction
Agrobacterium tumefaciens-mediated plant transformation.
Proposed Use

Production for human consumption and livestock feed.

Product Developer
Monsanto Company

Summary of Regulatory Approvals

Country Food Feed Environment Notes
Australia 2012
Canada 2012 2012 2012
Colombia 2015
European Union 2015 2015
Japan 2013 2013 2013
Korea 2013 2012
Mexico 2012 2012
New Zealand 2012
Philippines 2014 2014
Taiwan 2013
United States 2011 2011 2015
Vietnam 2015 2015

Introduction Expand

The intended effect of the modification in MON 87708 soybean is to produce dicamba tolerant soybeans. A conventional soybean variety was transformed with the dmo gene from Stenotrophomonas maltophilia strain DI6. The dmo gene encodes precursor proteins that after processing form a multisubunit enzyme (dicamba monooxygenase, DMO) that rapidly demethylates dicamba (3,6dichloro2methoxybenzoic acid) to the inactive metabolite 3,6dichlorosalicylic acid (DCSA), thereby conferring dicamba tolerance to the soybean.

Summary of Introduced Genetic Elements Expand

Code Name Type Promoter, other Terminator Copies Form
dmo dicamba mono-oxygenase HT

P-PC1SV promoter from peanut chlorotic streak virus; TS-RbcS chloroplast transit peptide from Pea RbcS2 gene.

T-E90 terminator from Pea RbcS2 gene.

1

Characteristics of Glycine max (Soybean) Expand

Center of Origin Reproduction Toxins Allergenicity

Southeast Asia; wild soybean species endemic in China, Korea, Japan, Taiwan.

Self-polinated; rarely displays any dormancy characteristics; does not compete well with other cultivated plants.

Raw soybeans contain trypsin inhibitors, which are toxin when eaten.

Soy allergies are common, and eating soy products can cause rashes and swelling of the skin in sensitive individuals.

Donor Organism Characteristics Expand

Latin Name Gene Pathogenicity
Stenotrophomonas maltophilia 5AT

The dmo gene is derived from the bacterium Stenotrophomonas maltophilia (Palleroni and Bradbury, 1993). S. maltophilia is an aerobic, ubiquitous environmental gram negative bacterium commonly present in aquatic environments, soil, and plants. S. maltophilia is ubiquitously associated with plants and has been isolated from the rhizosphere of wheat, maize, grasses, beet, cucumber, chicory, potato, strawberry, sugarcane, and rapeseed (Berg et al., 1996; Berg et al., 1999; Berg et al., 2002; Denton et

al., 1998; Echemendia, 2007; Juhnke and des Jardin, 1989; Juhnke et al., 1987; Lambert et al., 1987). S. maltophilia was isolated from cotton seed, bean pods, and coffee (Nunes and de Melo, 2006; Swings et al., 1983), thus, S. maltophilia can be found in a variety offoods and feeds.

It is also widespread in the home environment and can be found around dishwashers, sponges, toothbrushes, flowers, plants, fruits, vegetables, frozen fish, milk, and poultry (Ryan et al., 2009). Strains of S. maltophilia have been found in the transient flora of hospitalized patients as a commensal organism (Echemendia, 2007). Infections caused by S. maltophilia are extremely uncommon (Cunha, 2006), and S. maltophilia can be found in healthy individuals without causing any harm to human health (Denton et al., 1998). Similar to the indigenous bacteria of the gastrointestinal tract, S. maltophilia can be an opportunistic pathogen (Berg, 1996). As such, S. maltophilia is of low virulence in immuno-compromised patients where a series of factors must occur for colonization by S. maltophilia on humans (Ryan et al., 2009). 

Modification Method Expand

Coming soon.

Characteristics of the Modification Expand

Coming soon.

Environmental Safety Considerations Expand

Coming soon.

Food and/or Feed Safety Considerations Expand

Coming soon.

Links to Further Information Expand

Australia, FSANZ Canada, CFIA Canada, Health Canada EU, EC EU, EFSA Japan, BCH United States, FDA United States, USDA

This record was last modified on Wednesday, August 24, 2016