GM Crop Database

Database Product Description

MON87411 (MON-87411-9)
Host Organism
Zea mays (Maize)
Trait

Herbicide Tolerance, Insect Resistance

Trait Introduction
Agrobacterium tumefaciens-mediated plant transformation.
Proposed Use

Production for livestock feed.

Product Developer
Monsanto Company

Summary of Regulatory Approvals

Country Food Feed Environment Notes
Australia 2015
Brazil 2016 2016 2016
Canada 2015 2015 2015
Japan 2016 2016
Korea 2016 2016
New Zealand 2015
Taiwan 2015
United States 2014 2014 2015

Introduction Expand

Monsanto Company has developed MON87411 maize that confers protection against corn rootworm (CRW) (Diabrotica spp.) and tolerance to glyphosate. MON87411 contains a suppression cassette that expresses an inverted repeat sequence designed to match the sequence of western corn rootworm (WCR; Diabrotica virgifera virgifera). The expression of the suppression cassette results in the formation of a double-stranded RNA (dsRNA) transcript containing a 240 bp fragment of the WCR Snf7 gene (DvSnf7). Upon consumption, the plant-produced dsRNA in MON87411 is recognized by the CRW’s RNA interference (RNAi) machinery resulting in down-regulation of the targeted DvSnf7 gene leading to CRW mortality. MON87411 also contains a cry3Bb1 gene that produces a modified Bacillus thuringiensis (subsp. kumamotoensis) Cry3Bb1 protein to protect against CRW larval feeding. In addition, MON87411 contains the cp4 epsps gene from Agrobacterium sp. strain CP4 that encodes for the 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) protein, which confers tolerance to glyphosate, the active ingredient in Roundup. 

Summary of Introduced Genetic Elements Expand

Code Name Type Promoter, other Terminator Copies Form
dvsnf7 WCR Snf7 gene IR

P-e35S promoter from the 35S RNA of cauliflower mosaic virus (CaMV); the heat shock protein 70 (Hsp70) intron from Zea mays

The E9 gene 3' untranslated region from Pisum sativum

1

Inverted repeat sequence

cry3Bb1 cry3Bb1 delta-endotoxin IR

pIIG promoter from Zea mays; the chlorophyll a/b binding protein (CAB) leader from Triticum aestivum; the Ract1 intron from Oryza sativa

The heat shock protein 17 (Hsp17) 3′ untranslated region from Triticum aestivum

1

Codon optimized for plant expression

CP4 epsps 5-enolpyruvyl shikimate-3-phosphate synthase HT

TubA promoter from Oryza sativa; the TubA leader from Oryza sativa; the TubA intron from Oryza sativa; the CTP2 chloroplast-targeting sequence from Arabidopsis thaliana

The TubA 3′ untranslated region from Oryza sativa.

1

Codon optimized for plant expression

Characteristics of Zea mays (Maize) Expand

Center of Origin Reproduction Toxins Allergenicity

Mesoamerican region, now Mexico and Central America

Cross-pollination via wind-borne pollen is limited, pollen viability is about 30 minutes. Hybridization reported with teosinte species and rarely with members of the genus Tripsacum.

No endogenous toxins or significant levels of antinutritional factors.

Although some reported cases of maize allergy, protein(s) responsible have not been identified.

Donor Organism Characteristics Expand

Latin Name Gene Pathogenicity
Western Corn Rootworm (Diabrotica virgifera virgifera) dvsnf7

Western Corn Rootworm is one of the most devastating corn rootworm species in North America. There is no evidence in the literature that it is either toxic or allergenic to humans and animals. 

Bacillus thuringiensis subsp. kumamotoensis cry3Bb1 While coleopterans are susceptible to oral doses of Cry3Bb1 protein, there is no evidence of toxic effects in laboratory mammals or birds. There are no significant mammalian toxins or allergens associated with the host organism.
Agrobacterium tumefaciens strain CP4 CP4 epsps

Agrobacterium tumefaciens is a common soil bacterium that is responsible for causing crown gall disease in susceptible plants. There have been no reports of adverse effects on humans or animals.

Modification Method Expand

Coming soon.

Characteristics of the Modification Expand

Coming soon.

Environmental Safety Considerations Expand

Coming soon.

Food and/or Feed Safety Considerations Expand

Coming soon.

Links to Further Information Expand


This record was last modified on Friday, August 11, 2017