Database Product Description
- Host Organism
- Zea mays (Maize)
Herbicide tolerant, glyphosate; Insect resistant, Coleoptera; Insect resistant, Lepidoptera.
- Trait Introduction
- Traditional plant breeding and selection
- Proposed Use
Production for human consumption and livestock feed.
- Product Developer
- Monsanto Company
Summary of Regulatory Approvals
Summary of Introduced Genetic Elements Expand
Characteristics of Zea mays (Maize) Expand
Donor Organism Characteristics Expand
Modification Method Expand
Characteristics of the Modification Expand
Environmental Safety Considerations Expand
Food and/or Feed Safety Considerations Expand
MON810 X MON88017 (OECD identifier: MON-ØØ81Ø-6 X MON-88Ø17-3) maize is an F1 hybrid resulting from the hybridization of maize inbred MON 810 (MON-ØØ81Ø-6) with MON88017 (MON-88Ø17-3). This stacked maize hybrid is a product of traditional plant breeding, and therefore is not automatically subject to regulation in all jurisdictions as are transgenic plants resulting from recombinant DNA technologies. Certain jurisdictions may request notification in advance of the release of a stacked hybrid, or may request information to conduct an environmental and food safety assessment. Examples of jurisdictions that require either notification or information about stacked hybrids prior to their release into the environment, and for use in human food and livestock feed are Canada and Japan.
The stacked hybrid MON810 X MON88017 expresses three novel proteins: CP4 EPSPS which confers tolerance to the herbicide glyphosate, and the delta-endotoxins Cry1Ab, which confers resistance to the European Corn Borer and other lepidopterans, and Cry3Bb1 which confers resistance to Corn Rootworm. The insecticidal protein Cry1Ab, is produced by the cry1Ab gene from MON810. The insecticidal protein Cry3Bb1, is produced by the cry3Bb1 gene and the CP4 EPSPS protein is produced by the cp4 epsps gene both from MON88017. The novel traits of each parent line have been combined, through traditional plant breeding, to produce this new hybrid. For a full description of each parent line please refer to the individual product descriptions in the crop database for MON810 and MON88017.
The inserted genes and their gene products have a history of safe use, and have undergone review and approval by several regulatory agencies. No interactions among the gene products or negative synergistic effects are expected in the stacked hybrid. The Cry1Ab and Cry3Bb1 proteins are not enzymes and therefore do not affect plant metabolism. The CP4 EPSPS has high affinity for its substrates phosphoenolpyruvate (PEP) and shikimate-3-phosphate, which are part of the shikimate metabolic pathway. These proteins are therefore not expected to interact within, nor affect the metabolism of the stacked hybrid
Links to Further Information Expand
This record was last modified on Wednesday, July 6, 2016