GM Crop Database

Database Product Description

MON805
Host Organism
Zea mays (Maize)
Trait

Herbicide Tolerance, Insect Resistance

Trait Introduction
Direct DNA transfer system
Proposed Use

Production for human consumption and livestock feed.

Product Developer
Monsanto Company

Summary of Regulatory Approvals

Country Food Feed Environment Notes
United States 1996 1996

Introduction Expand

On July 2, 1996, Monsanto Company submitted summary information on several genetically engineered maize lines including MON 805 to support their safety and nutritional assessment. MON 805 is a maize line resulting from genetic modifications to confer resistance to the feeding of the European Corn Borer (ECB) (a lepidopteran pest insect) and to confer tolerance to glyphosate. Insect resistance (to ECB) is conferred by the insecticidal protein Cry1Ab, which is originally from Bacillus thuringiensis. Glyphosate resistance is due to expression of the protein 5-enolpyruvylshikimate-3-phosphate synthase (CP4 EPSPS). The introduced glyphosate oxidoreductase (GOX) protein also confers glyphosate tolerance. The maize line is also resistant to the feeding of another lepidopteran pest insect, the southwestern corn borer. 

Summary of Introduced Genetic Elements Expand

Code Name Type Promoter, other Terminator Copies Form
CP4 epsps 5-enolpyruvyl shikimate-3-phosphate synthase HT

E35S promoter and the corn hsp70 intron

NOS 3' termination sequence

1
cry1Ab Cry1Ab delta-endotoxin IR

E35S promoter and the corn hsp70 intron

NOS 3' termination sequence

1
nptII neomycin phosphotransferase II SM

bacterial promoter

1 complete, 1 rearranged

Not expressed in plant tissues because of bacterial promoter

gox glyphosate oxidoreductase HT

E35S promoter and the corn hsp70 intron

NOS 3' termination sequence

1

Characteristics of Zea mays (Maize) Expand

Center of Origin Reproduction Toxins Allergenicity

Mesoamerican region, now Mexico and Central America

Cross-pollination via wind-borne pollen is limited, pollen viability is about 30 minutes. Hybridization reported with teosinte species and rarely with members of the genus Tripsacum.

No endogenous toxins or significant levels of antinutritional factors.

Although some reported cases of maize allergy, protein(s) responsible have not been identified.

Donor Organism Characteristics Expand

Latin Name Gene Pathogenicity
Agrobacterium tumefaciens strain CP4 CP4 epsps

Agrobacterium tumefaciens is a common soil bacterium that is responsible for causing crown gall disease in susceptible plants. There have been no reports of adverse effects on humans or animals.

Bacillus thuringiensis cry1Ab

While target insects are susceptible to oral doses of Bt proteins, no evidence of toxic effects in laboratory mammals or birds given up to 10 µg protein/g body weight.

Ochromobactrum anthropii strain LBAA gox

O. anthropi, formerly known as Achromobacter species (CDC group Vd), is a common soil alphaproteobacteria that colonizes a wide spectrum of organisms and is being increasingly recognized as a potentially problematic opportunistic and nosocomial human pathogen. Though it is extremely rare for it to affect a healthy human, there have been numerous published cases being associated with the presence of indwelling medical devices, such as central venous catheters, drainage tubes, and intraperitoneal catheters. It is also characterized by a broad spectrum of antibiotic resistance.

Modification Method Expand

Coming soon.

Characteristics of the Modification Expand

Coming soon.

Environmental Safety Considerations Expand

Coming soon.

Food and/or Feed Safety Considerations Expand

Coming soon.

Links to Further Information Expand


This record was last modified on Monday, February 13, 2017