GM Crop Database

MON805

Country	Food	Feed	Environment	Notes
United States	1996	1996

Introduction Expand: On July 2, 1996, Monsanto Company submitted summary information on several genetically engineered maize lines including MON 805 to support their safety and nutritional assessment. MON 805 is a maize line resulting from genetic modifications to confer resistance to the feeding of the European Corn Borer (ECB) (a lepidopteran pest insect) and to confer tolerance to glyphosate. Insect resistance (to ECB) is conferred by the insecticidal protein Cry1Ab, which is originally from Bacillus thuringiensis. Glyphosate resistance is due to expression of the protein 5-enolpyruvylshikimate-3-phosphate synthase (CP4 EPSPS). The introduced glyphosate oxidoreductase (GOX) protein also confers glyphosate tolerance. The maize line is also resistant to the feeding of another lepidopteran pest insect, the southwestern corn borer.

Summary of Introduced Genetic Elements Expand

Code	Name	Type	Promoter, other	Terminator	Copies	Form
CP4 epsps	5-enolpyruvyl shikimate-3-phosphate synthase	HT	E35S promoter and the corn hsp70 intron	NOS 3' termination sequence	1
cry1Ab	Cry1Ab delta-endotoxin	IR	E35S promoter and the corn hsp70 intron	NOS 3' termination sequence	1
nptII	neomycin phosphotransferase II	SM	bacterial promoter		1 complete, 1 rearranged	Not expressed in plant tissues because of bacterial promoter
gox	glyphosate oxidoreductase	HT	E35S promoter and the corn hsp70 intron	NOS 3' termination sequence	1

Characteristics of Zea mays (Maize) Expand

Center of Origin	Reproduction	Toxins	Allergenicity
Mesoamerican region, now Mexico and Central America	Cross-pollination via wind-borne pollen is limited, pollen viability is about 30 minutes. Hybridization reported with teosinte species and rarely with members of the genus Tripsacum.	No endogenous toxins or significant levels of antinutritional factors.	Although some reported cases of maize allergy, protein(s) responsible have not been identified.

Donor Organism Characteristics Expand

Latin Name	Gene	Pathogenicity
Agrobacterium tumefaciens strain CP4	CP4 epsps	Agrobacterium tumefaciens is a common soil bacterium that is responsible for causing crown gall disease in susceptible plants. There have been no reports of adverse effects on humans or animals.
Bacillus thuringiensis	cry1Ab	While target insects are susceptible to oral doses of Bt proteins, no evidence of toxic effects in laboratory mammals or birds given up to 10 µg protein/g body weight.
Ochromobactrum anthropii strain LBAA	gox	O. anthropi, formerly known as Achromobacter species (CDC group Vd), is a common soil alphaproteobacteria that colonizes a wide spectrum of organisms and is being increasingly recognized as a potentially problematic opportunistic and nosocomial human pathogen. Though it is extremely rare for it to affect a healthy human, there have been numerous published cases being associated with the presence of indwelling medical devices, such as central venous catheters, drainage tubes, and intraperitoneal catheters. It is also characterized by a broad spectrum of antibiotic resistance.

Links to Further Information Expand

United States, FDA

This record was last modified on Monday, February 13, 2017