Database Product Description
- Host Organism
- Gossypium hirsutum (Cotton)
- Resistance to lepidopteran pests and glyphosate herbicide tolerance
- Trait Introduction
- Traditional plant breeding and selection
- Proposed Use
Production for fibre, livestock feed, and human consumption.
- Product Developer
- Monsanto Company
Summary of Regulatory Approvals
Summary of Introduced Genetic Elements Expand
Characteristics of Gossypium hirsutum (Cotton) Expand
Donor Organism Characteristics Expand
Modification Method Expand
Characteristics of the Modification Expand
Environmental Safety Considerations Expand
Food and/or Feed Safety Considerations Expand
MON531 X MON1445 (OECD identifier: MON-ØØ531-6 x MON-Ø1445-2) cotton is the product of the cross-breeding of the insect-resistant cotton line MON531 (MON-ØØ531-6) with the herbicide-tolerant cotton line MON1445 (MON-Ø1445-2). This stacked cotton line is a product of traditional plant breeding, and therefore is not automatically subject to regulation in all jurisdictions as are transgenic plants resulting from recombinant DNA technologies. Certain jurisdictions may request notification in advance of the release of a stacked hybrid, or may request information to conduct an environmental and food safety assessment. Examples of jurisdictions that require either notification or information about stacked hybrids prior to their release into the environment, and for use in human food and livestock feed are Canada and Japan.
The stacked cotton line MON531 X MON1445 expresses two novel proteins: the delta-endotoxin Cry1Ac which confers resistance to the lepidopteran pests of cotton, such as the cotton bollworm, pink bollworm and tobacco budworm, and the CP4 EPSPS protein which confers tolerance to the herbicide glyphosate. The insecticidal protein is produced by the cry1Ac gene from MON531, and the CP4 EPSPS protein is cp4 epsps gene from MON1445. The novel traits of each parental line have been combined, through traditional plant breeding, to produce this new cotton line. For a full description of each parental line please refer to the individual product descriptions in the crop database for MON531 and MON1445.
The inserted genes and their gene products have a history of safe use, and have undergone review and approval by several regulatory agencies. No interactions among the gene products or negative synergistic effects are expected in the stacked hybrid. The Cry1Ac protein is not an enzyme and therefore does not affect plant metabolism. The CP4 EPSPS has high affinity for its substrates phosphoenolpyruvate (PEP) and shikimate-3-phosphate, which are part of the shikimate metabolic pathway. CP4 EPSPS and Cry1Ac are therefore not expected to interact within, nor affect the metabolism of the stacked line.
Studies were conducted to compare the resistance to lepidopterans and tolerance to glyphosate between the stacked cotton line and each parental line. There were no significant differences in the stacked line in the resistance to the lepidopteran pests, or in the tolerance to applications of glyphosate, compared to the parental lines.
Links to Further Information Expand
This record was last modified on Tuesday, August 23, 2016