GM Crop Database

Database Product Description

MON 87769 (MON-87769-7)
Host Organism
Glycine max (Soybean)
Trait
Product Quality
Trait Introduction
Agrobacterium tumefaciens-mediated plant transformation.
Proposed Use

Production for human consumption and livestock feed.

Product Developer
Monsanto Company

Summary of Regulatory Approvals

Country Food Feed Environment Notes
Australia 2011
Canada 2011 2011 2011
Colombia 2014 2012
European Union 2015 2015
Indonesia 2015
Japan 2014 2014 2014
Korea 2013 2012
Mexico 2012 2012
New Zealand 2011
Philippines 2015 2015
Taiwan 2013
United States 2012 2012 2011
Vietnam 2015 2015

Introduction Expand

Monsanto has developed biotechnology-derived soybean MON 87769 that contains stearidonic acid (SDA; 18:4), a sustainable alternate source of an omega-3 fatty acid to help meet the needed dietary intake of long chain omega-3 fatty acids. The production of

SDA in MON 87769 is accomplished through the introduction of two desaturase genes, Primula juliae Δ6 desaturase (Pj.D6D) and Neurospora crassa Δ15 desaturase (Nc.Fad3) into conventional soybean, A3525. The two introduced genes encode for the PjΔ6D and

NcΔ15D proteins, respectively. SDA is an 18-carbon fatty acid with four double bonds (18:4) and is found in plants, fish and fish/algal oil products. In mammals, SDA is a metabolic intermediate in the production of eicosapentaenoic acid (EPA; 20:5) and docosahexaenoic acid (DHA; 22:6) from alpha linolenic acid (ALA; 18:3), a common dietary constituent. In addition to SDA, MON 87769 contains approximately 7% γ- linolenic acid (GLA; 18:3), which is an in vivo metabolite in the conversion of linoleic acid (LA: 18:2) to arachidonic acid (20:4) in mammals.

Summary of Introduced Genetic Elements Expand

Code Name Type Promoter, other Terminator Copies Form
Pj.D6D delta-desaturase PQ

7Sa’ Sphas1 promoter from soybean.

tm1 3’ untranslated region from Agrobacterium tumefaciens.

1
epsps 5-enol-pyruvylshikimate-3-phosphate synthase SM

FMV promoter from figwort mosaic virus; CTP2 chloroplast transit protein from Arabidopsis thaliana.

E9 rbcS2 terminator from pea.

1

Codon optimized for plant expression.

Nc.Fad3 delta 15 desaturase PQ

7Sa’ Sphas1 promoter from soybean.

E9 rbcS2 terminator from pea.

1

codons optimized for plant expression.

Characteristics of Glycine max (Soybean) Expand

Center of Origin Reproduction Toxins Allergenicity

Southeast Asia; wild soybean species endemic in China, Korea, Japan, Taiwan.

Self-polinated; rarely displays any dormancy characteristics; does not compete well with other cultivated plants.

Raw soybeans contain trypsin inhibitors, which are toxin when eaten.

Soy allergies are common, and eating soy products can cause rashes and swelling of the skin in sensitive individuals.

Donor Organism Characteristics Expand

Latin Name Gene Pathogenicity
Primula juliae 5AT

Primula juliae is a plant cultivated for its flowers and in the production of improved horticultural primrose varieties. It is not known to be either pathogenic or allergenic.

Agrobacterium tumefaciens strain CP4 CP4 epsps

Agrobacterium tumefaciens is a common soil bacterium that is responsible for causing crown gall disease in susceptible plants. There have been no reports of adverse effects on humans or animals.

Neurospora crassa 5AT

Neurospora crassa is a ubiquitous fungus that causes red bread mold. It is not known to have pathogenic properties, however it does produce glucoamylase, a known allergen.

Modification Method Expand

Coming soon.

Characteristics of the Modification Expand

Coming soon.

Environmental Safety Considerations Expand

Coming soon.

Food and/or Feed Safety Considerations Expand

Coming soon.

Links to Further Information Expand

Australia, FSANZ Canada, CFIA Canada, Health Canada Colombia, El Ministro de Salud y Proteccion Social EU, EC EU, EFSA Japan, BCH Philippines, DOA United States, FDA United States, USDA

This record was last modified on Thursday, September 22, 2016