GM Crop Database

Database Product Description

Host Organism
Zea mays (Maize)
Herbicide Tolerance
Trait Introduction
Direct DNA transfer system
Proposed Use

Production for human consumption and livestock feed.

Product Developer
Stine Biotechnology

Summary of Regulatory Approvals

Country Food Feed Environment Notes
Canada 2014 2014 2014
United States 2012 2012 2013

Introduction Expand

Maize line HCEM485 was developed to be glyphosate herbicide-tolerant by introducing a 6.0 kb maize genomic fragment containing a double mutated form of the endogenous maize EPSPS encoding gene (2mEPSPS). The gene was introduced via aerosol beam injector, a naked DNA delivery tool. Except for the introduced mutations, the amino acid sequence of 2mEPSPS enzyme expressed in HCEM485 is identical to that of the EPSPS enzyme in the native wild-type maize. 

Summary of Introduced Genetic Elements Expand

Code Name Type Promoter, other Terminator Copies Form
epsps 5-enol-pyruvylshikimate-3-phosphate synthase HT

5’ region of the maize (Z. mays)EPSPS-encoding gene containing native promoter sequences

3’ nontranslated region of the native maize (Z. mays) EPSPS-encoding gene


The mutations result in a glyphosate-tolerant form of the enzyme

Characteristics of Zea mays (Maize) Expand

Center of Origin Reproduction Toxins Allergenicity

Mesoamerican region, now Mexico and Central America

Cross-pollination via wind-borne pollen is limited, pollen viability is about 30 minutes. Hybridization reported with teosinte species and rarely with members of the genus Tripsacum.

No endogenous toxins or significant levels of antinutritional factors.

Although some reported cases of maize allergy, protein(s) responsible have not been identified.

Donor Organism Characteristics Expand

Latin Name Gene Pathogenicity
Zea mays epsps

Not applicable.

Modification Method Expand

Coming soon.

Characteristics of the Modification Expand

Coming soon.

Environmental Safety Considerations Expand

Coming soon.

Food and/or Feed Safety Considerations Expand

Coming soon.

Links to Further Information Expand

This record was last modified on Thursday, December 15, 2016