GM Crop Database

Database Product Description

GM Shanyou 63
Host Organism
Oryza sativa (Rice)
Multiple Insect Resistance Traits
Trait Introduction
Microparticle bombardment of plant cells or tissue
Proposed Use

Production for human consumption, animal feed, and industrial products.

Product Developer
Huazhong Agricultural University

Summary of Regulatory Approvals

Country Food Feed Environment Notes
China 2009 2009 2009

Introduction Expand

GE rice Bt Shanyou63, with the introduced cry1Ab/Ac gene to confer resistance to lepidopterous insects, was created through crossbreeding between a GE rice Huahui 1 and a sterile line Zhenshan 97A. Huahui 1 is free of the selectable marker gene - hygromycin phosphotransferase gene (hph), eliminating the biosafety concerns associated with antibiotic marker genes. The results showed that Bt Shanyou 63 had a significant effect on controlling stem borers without affecting the surrounding environment and other plants. The nutrient contents of Huahui 1 and its original cultivar Minghui 63 are largely the same. Oral feeding and toxicology studies (including acute toxicities, mutagenicity, traditional teratogenicity, 3-generation reproductivity, chronic toxicity, and carcinogenicity) confirmed that the Huahui 1 rice has no acute, progressive, or irreversible toxicity, teratogenic, or carcinogenic effects in the rats or mice under study, or their embryos of any generation. 

Summary of Introduced Genetic Elements Expand

Code Name Type Promoter, other Terminator Copies Form
cry1Ab-Ac Cry1Ab delta-endotoxin IR

actinI promoter from oryza sativa (rice)

nos terminator (synthetic)

hyg hygromycin B phosphotransferase SM

35S promoter from Cauliflower mosaic virus (CaMV) 

35S terminator from CaMV


Selectable marker, not in the final product

Characteristics of Oryza sativa (Rice) Expand

Center of Origin Reproduction Toxins Allergenicity
Northern India and Southeast Asia, and southern China are believed to be the centre of origin of Asian rice (O. sativa). Wild progenitors of African cultivated rice (O. glaberrima) are grasses endemic to West Africa. Basically an autogamous plant propagating through seeds produced by self-pollination. Cross pollination between wild species and O. sativa cultivars has been reported to occur in natural habitats. Antinutrients including phytic acid, trypsin inhibitor, hemagglutinins (lectins) are present in the bran fraction. Allergenic proteins, 14-15 kDa range, present in the albumin plus globulin protein fraction from rice endosperm. Major 16 kDa allergenic protein is a member of the alpha-amylase/trypsin inhibitor family of proteins.

Donor Organism Characteristics Expand

Latin Name Gene Pathogenicity
Bacillus thuringiensis subsp. kurstaki cry1Ab-Ac

While target insects are susceptible to oral doses of Bt proteins, no evidence of toxic effects in laboratory mammals or birds given up to 10 µg protein/g body weight.

Escherichia coli (K-12) hyg

Escherichia coli is one of a number of microorganisms which are normal inhabitants of the colons of virtually all warm-blooded mammals. Ecoli belongs to the taxonomic family known asEnterobacteriaceae, which is one of the best-defined groups of bacteria. The strain Ecoli K-12 is a debilitated strain which does not normally colonize the human intestine. It has also been shown to survive poorly in the environment, has a history of safe commercial use, and is not known to have adverse effects on microorganisms or plants. 

Modification Method Expand

Coming soon.

Characteristics of the Modification Expand

Coming soon.

Environmental Safety Considerations Expand

Coming soon.

Food and/or Feed Safety Considerations Expand

Coming soon.

Links to Further Information Expand

This record was last modified on Monday, February 13, 2017