GM Crop Database

Database Product Description

Bt11 x MIR162 x GA21 (SYN-BTØ11-1 x SYN-IR162-4 x MON-ØØØ21-9)
Host Organism
Zea mays (Maize)
Resistance to a range of lepidopteran insect pests; phosphinothricin (PPT) herbicide tolerance, specifically glufosinate ammonium.
Trait Introduction
Traditional plant breeding and selection
Proposed Use

Production for human consumption and livestock feed.

Product Developer
Syngenta Seeds, Inc.

Summary of Regulatory Approvals

Country Food Feed Environment Notes
Argentina 2011 2011 2011
Brazil 2010 2010 2010
Colombia 2012 2010
European Union 2016 2016
Japan 2010 2010 2010
Korea 2012 2011
Mexico 2010 2010
Paraguay 2015 2015 2015
Philippines 2010 2010
South Africa 2011 2011
Taiwan 2011
Uruguay 2012 2012 2012

Introduction Expand

This stacked maize hybrid is a product of traditional plant breeding, and is therefore not automatically subject to regulation in all countries, unlike transgenic plants resulting from recombinant-DNA technologies. The approvals table above does not include entries from these countries. Other countries may request notification in advance of the release of a stacked hybrid, or may request information to conduct an environmental and food safety assessment, and these countries’ decisions are reflected in the approvals table.

Summary of Introduced Genetic Elements Expand

Code Name Type Promoter, other Terminator Copies Form
cry1Ab Cry1Ab delta-endotoxin IR

CaMV 35S

IVS 6 intron from the maize alcohol dehydrogenase gene

A. tumefaciens nopaline synthase (nos) 3'-untranslated region


Truncated, modified

pat phosphinothricin N-acetyltransferase HT CaMV 35S IVS 2 intron from the maize alcohol dehydrogenase gene A. tumefaciens nopaline synthase (nos) 3'-untranslated region 1 Modified for enhanced expression
epsps 5-enolpyruvylshikimate-3-phosphate synthase HT

rice actin I promoter and intron sequences

; ribulose-1,5-bisphosphate carboxylase oxygenase (RuBisCo) derived chloroplast transit peptide squences (from corn & sunflower)

A. tumefaciens nopaline synthase (nos) 3'-untranslated region


Modified by in vitro mutagenesis; single insertion site with 3 complete copies of EPSPS cassette plus 3 incomplete copies

vip3A(a) vegetative insecticidal protein IR

ZmUbiInt (Zea mays polyubiquitin gene promoter and first intron).

CaMV 35S 3' polyadenylation signal



pmi mannose-6-phosphate isomerase SM ZmUbiInt (Zea mays poly-ubiquitin gene promoter and first intron) A. tumefaciens nopaline synthase (nos) 3'-untranslated region 1

Characteristics of Zea mays (Maize) Expand

Center of Origin Reproduction Toxins Allergenicity

Mesoamerican region, now Mexico and Central America

Cross-pollination via wind-borne pollen is limited, pollen viability is about 30 minutes. Hybridization reported with teosinte species and rarely with members of the genus Tripsacum.

No endogenous toxins or significant levels of antinutritional factors.

Although some reported cases of maize allergy, protein(s) responsible have not been identified.

Donor Organism Characteristics Expand

Latin Name Gene Pathogenicity
Bacillus thuringiensis subsp. kurstaki EC2.4.2.19

While target insects are susceptible to oral doses of Bt proteins, no evidence of toxic effects in laboratory mammals or birds given up to 10 µg protein/g body weight.

Streptomyces viridochromogenes pat

S. viridochromogenes is ubiquitous in the soil. It exhibits very slight antimicrobial activity, is inhibited by streptomycin, and there have been no reports of adverse affects on humans, animals, or plants.

Bacillus thuringiensis strain AB88 5AT

While target lepidopteran insects are susceptible to oral doses of VIP proteins, there is no evidence of toxic effects in laboratory mammals, in birds, and in non-target arthropods, including beneficial insects.

Modification Method Expand

Coming soon.

Characteristics of the Modification Expand

Coming soon.

Environmental Safety Considerations Expand

Coming soon. 

Food and/or Feed Safety Considerations Expand

Coming soon.

Links to Further Information Expand

Brazil Ministry of Science and Technology - MCT The National Biosafety Technical - CTNBio Executive Secretary Instituto Colombiano Agropecuario ICA Japan Mnistry of Health, Labor and Welfare Mexico SECRETARIA DE SALUD-COFEPRIS Ministerio de Agricultura, Ganaderia y Pesca (Brasil) Ministerio de Salud Proteccion Social Philippine Department of Agriculture Secretariat of Agriculture, Livestock, Fisheries and Food Argentina Uruguay National Biosafety Cabinet

This record was last modified on Friday, August 11, 2017