GM Crop Database

Database Product Description

Bt11 x 59122 x MIR604 x TC1507 x GA21 (SYN-BTØ11-1 x DAS-59122-7 x SYN-IR6Ø4-5 x DAS-Ø15Ø7-1 x MON-ØØØ21-9)

Host Organism

Zea mays (Maize)

Trait

Herbicide tolerant, glufosinate ammonium; Herbicide tolerant, glyphosate; Insect resistant, Coleoptera; Insect resistant, Lepidoptera.

Trait Introduction

Traditional plant breeding and selection

Proposed Use

Production for human consumption and livestock feed.

Product Developer

Syngenta Seeds, Inc.

Summary of Regulatory Approvals

Introduction Expand

Coming soon.

Summary of Introduced Genetic Elements Expand

Code	Name	Type	Promoter, other	Terminator	Copies	Form
cry1Ab	Cry1Ab delta-endotoxin	IR	35S promoter from Cauliflower Mosaic Virus; IVS6-ADH1 enhancer from Zea mays	NOS terminator from Agrobacterium tumefaciens		Sequence was modified for plant codon preference
cry1F	Cry1F delta-endotoxin	IR	UBIZM1(2) ubiquitin promoter from Zea mays	ORF25PolyA terminator from A. tumefaciens
cry34Ab1	Cry34Ab1 delta-endotoxin	IR	UBI1ZM PRO ubiquitin promoter from Zea mays	PIN II TERM protease inhibitor terminator from Solanum tuberosum
cry35Ab1	Cry35Ab1 delta-endotoxin	IR	TA Peroxidase PRO peroxidase promoter from Triticum aestivum	PIN II TERM protease inhibitor terminator from Solanum tuberosum
mcry3A	Cry3A delta-endotoxin	IR	MTL metallothionein promoter from Zea mays	NOS terminator from A. tumefaciens
pat	Phosphinothricin acetyltransferase	HT	35S promoter from Cauliflower Mosaic Virus; IVS6-ADH1 enhancer from Zea mays	NOS terminator from Agrobacterium tumefaciens		Sequence was modified for plant codon preference
pat	Phosphinothricin acetyltransferase	HT	35S PRO promoter from Cauliflower Mosaic Virus	35S TERM terminator from Cauliflower Mosaic Virus
pmi	Phosphomannose isomerase	SM	ZmUbiInt polyubiquitin promoter from Zea mays	NOS terminator from A. tumefaciens
epsps	5-enol-pyruvyl-shikimate-3-phospphate synthase	HT	Act actin promoter from Oryza sativa; sssu+mssu RuBisCo transit peptides from Zea mays and Helianthus annuus	NOS terminator from A. tumefaciens

Characteristics of Zea mays (Maize) Expand

Center of Origin	Reproduction	Toxins	Allergenicity
Mesoamerican region, now Mexico and Central America	Cross-pollination via wind-borne pollen is limited, pollen viability is about 30 minutes. Hybridization reported with teosinte species and rarely with members of the genus Tripsacum.	No endogenous toxins or significant levels of antinutritional factors.	Although some reported cases of maize allergy, protein(s) responsible have not been identified.

Donor Organism Characteristics Expand

Latin Name	Gene	Pathogenicity
Bacillus thuringiensis subsp. kurstaki	cry1Ac	Although target insects are susceptible to oral doses of Bt proteins, there is no evidence of toxic effects in laboratory mammals or bird given up to 10 µg protein / g body wt. There are no significant mammalian toxins or allergens associated with the host organism.
Bacillus thuringiensis var. aizawai	cry1F	While target insects are susceptible to oral doses of Bt proteins, no evidence of toxic effects in laboratory mammals or birds.
Bacillus thuringiensis	cry1Ab	While target insects are susceptible to oral doses of Bt proteins, no evidence of toxic effects in laboratory mammals or birds given up to 10 µg protein/g body weight.
Bacillus thuringiensis	cry1Ab	While target insects are susceptible to oral doses of Bt proteins, no evidence of toxic effects in laboratory mammals or birds given up to 10 µg protein/g body weight.
Bacillus thuringiensis subsp. Tenebrionis	cry3A	While beetles and other coleopterans are susceptible to oral doses of Cry3A protein, there is no evidence of toxic effects in laboratory mammals or birds. There are no significant mammalian toxins or allergens associated with the host organism.
Streptomyces viridochromogenes	pat	S. viridochromogenes is ubiquitous in the soil. It exhibits very slight antimicrobial activity, is inhibited by streptomycin, and there have been no reports of adverse affects on humans, animals, or plants.
Streptomyces viridochromogenes	pat	S. viridochromogenes is ubiquitous in the soil. It exhibits very slight antimicrobial activity, is inhibited by streptomycin, and there have been no reports of adverse affects on humans, animals, or plants.
Escherichia coli (K-12)	hyg	Escherichia coli is one of a number of microorganisms which are normal inhabitants of the colons of virtually all warm-blooded mammals. E. coli belongs to the taxonomic family known asEnterobacteriaceae, which is one of the best-defined groups of bacteria. The strain E. coli K-12 is a debilitated strain which does not normally colonize the human intestine. It has also been shown to survive poorly in the environment, has a history of safe commercial use, and is not known to have adverse effects on microorganisms or plants.
Zea mays	epsps	Not applicable.

Modification Method Expand

Coming soon.

Characteristics of the Modification Expand

Coming soon.

Environmental Safety Considerations Expand

Coming soon.

Food and/or Feed Safety Considerations Expand

Coming soon.

Links to Further Information Expand

Japan Biosafety Clearing House

• Maize resistant to Lepidoptera and Coleoptera, and tolerant to glufosinate herbicide and glyphosate herbicide (modified cry1Ab, cry34Ab1, cry35Ab1, modified cry3Aa2, cry1F, pat, mEPSPS, Zea mays subsp. mays (L.) Iltis) (Bt11×B.t. Cry34/35Ab1 Event DAS-59122-7×MIR604×B.t. Cry1F maize line 1507×GA21, OECD UI： SYN-BTØ11-1× DAS-59122-7×SYN-IR6Ø4-5×DAS-Ø15Ø7-1×MON-ØØØ21-9)
  [PDF Size: 174.55K bytes]

Phillippine Department of Agriculture

• Determination of the Safety of Syngenta's Combined trait product corn: Bt11 x DAS59122 xMIR604 x TC1507 x GA21 for Direct use as Food, Feed, or Processing

This record was last modified on Monday, July 3, 2017