GM Crop Database

Database Product Description

BT11 x MIR162 x MIR604 (SYN-BTØ11-1xSYN-IR162-4xSYN-IR6Ø4-5)
Host Organism
Zea mays (Maize)
Trait

Herbicide tolerant, glufosinate ammonium; Insect resistant, Coleoptera; Insect resistant, Lepidoptera.

Trait Introduction
Traditional plant breeding and selection
Proposed Use

Production for human consumption and livestock feed.

Product Developer
Syngenta Seeds, Inc.

Summary of Regulatory Approvals

Country Food Feed Environment Notes
European Union 2016 2016
Japan 2010 2010 2010
United States 2009 View

Introduction Expand

This stacked maize hybrid is a product of traditional plant breeding, and is therefore not automatically subject to regulation in all countries, unlike transgenic plants resulting from recombinant-DNA technologies. The approvals table above does not include entries from these countries. Other countries may request notification in advance of the release of a stacked hybrid, or may request information to conduct an environmental and food safety assessment, and these countries’ decisions are reflected in the approvals table.

BT11 x MIR162 x MIR604 provides insect protection against European corn borer (Ostrinia nubilalis), southwestern corn borer (Diatraea grandiosella), southern cornstalk borer (Diatraea crambidoides), corn earworm (Helicoverpa zea), fall armyworm (Spodoptera frugiperda), armyworm (Pseudaletia unipunctata), beet armyworm (Spodoptera exigua), black cutworm (Agrotis ipsilon), western bean cutworm (Striacosta albicosta), sugarcane borer (Diatraea saccharalis), common stalk borer (Papaipema nebris), western corn rootworm (Diabrotica virgifera virgifera), northern corn rootworm (Diabrotica barberi), and Mexican corn rootworm (Diabrotica virgifera zeae). Tolerance to glufosinate-ammonium containing herbicides is conferred through expression of the pat gene derived from BT11.

For a full description of each parental line please refer to the individual product descriptions in the crop database for BT11 and MIR162 and MIR604.

Summary of Introduced Genetic Elements Expand

Code Name Type Promoter, other Terminator Copies Form
cry1Ab Cry1Ab delta-endotoxin (Btk HD-1) IR CaMV 35S IVS 6 intron from the maize alcohol dehydrogenase gene A. tumefaciens nopaline synthase (nos) 3'-untranslated region 1 Truncated, modified
pat phosphinothricin N-acetyltransferase HT CaMV 35S IVS 2 intron from the maize alcohol dehydrogenase gene A. tumefaciens nopaline synthase (nos) 3'-untranslated region 1 Modified for enhanced expression
vip3Aa20 vegetative insecticidal protein IR ZmUbiInt (Zea mays poly-ubiquitin gene promoter and first intron) CaMV 35S 3' poly-adenylation signal 1 native
pmi mannose-6-phosphate isomerase SM ZmUbiInt (Zea mays poly-ubiquitin gene promoter and first intron) A. tumefaciens nopaline synthase (nos) 3'-untranslated region 2
mcry3A Cry3A delta-endotoxin IR promoter derived from the metallo-thionein-like gene from Zea mays A. tumefaciens nopaline synthase (nos) 3'-untranslated region 1 Modified to enhance expression in maize

Characteristics of Zea mays (Maize) Expand

Center of Origin Reproduction Toxins Allergenicity

Mesoamerican region, now Mexico and Central America

Cross-pollination via wind-borne pollen is limited, pollen viability is about 30 minutes. Hybridization reported with teosinte species and rarely with members of the genus Tripsacum.

No endogenous toxins or significant levels of antinutritional factors.

Although some reported cases of maize allergy, protein(s) responsible have not been identified.

Donor Organism Characteristics Expand

Latin Name Gene Pathogenicity
Bacillus thuringiensis subsp. kurstaki EC2.4.2.19

While target insects are susceptible to oral doses of Bt proteins, no evidence of toxic effects in laboratory mammals or birds given up to 10 µg protein/g body weight.

Streptomyces viridochromogenes pat

S. viridochromogenes is ubiquitous in the soil. It exhibits very slight antimicrobial activity, is inhibited by streptomycin, and there have been no reports of adverse affects on humans, animals, or plants.

Bacillus thuringiensis strain AB88 5AT

While target lepidopteran insects are susceptible to oral doses of VIP proteins, there is no evidence of toxic effects in laboratory mammals, in birds, and in non-target arthropods, including beneficial insects.

Modification Method Expand

Coming soon. 

Characteristics of the Modification Expand

Coming soon. 

Environmental Safety Considerations Expand

Coming soon. 

Food and/or Feed Safety Considerations Expand

Coming soon. 

Links to Further Information Expand

United States Environmental Protection Agency

This record was last modified on Friday, August 4, 2017