GM Crop Database

Database Product Description

123.8.12 (FLO-4Ø689-6)
Host Organism
Dianthus caryophyllus (Carnation)

Herbicide Tolerance, Product Quality

Trait Introduction
Agrobacterium tumefaciens-mediated plant transformation.
Proposed Use

Production for the cut-flower industry.

Product Developer
Florigene Pty Ltd.

Summary of Regulatory Approvals

Country Food Feed Environment Notes
Australia 2015 View
European Union 2009 View
Japan 2009
Malaysia 2012 View
Netherlands 2007 View

Introduction Expand

Through event 123.8.12 (OECD Unique Identifier FLO-4Ø689-6), carnation produces mauve-colored flowers, whereas the non-GM parent plant has white flowers. The color change was achieved by introducing from Petunia and Viola sp. two genes in the anthocyanin biosynthesis pathway. The two genes encode two enzymes - dihydroflavonol 4-reductase (dfr) and flavonoid 3'5' hydroxylase (f3'5'h). In addition, this genetically engineered carnation contains a marker gene SuRB, which confers the plant tolerance to sulphonylurea-type herbicides. 

Summary of Introduced Genetic Elements Expand

Code Name Type Promoter, other Terminator Copies Form
F3’5’H flavonoid-3’,5’-hydroxylase PM

Chalcone synthase gene (CHS)

D8 gene terminator (D8 3’)

dfr dihydroflavonol reductase PM

dfr promoter

dfr terminator

surB acetolactate synthase SM

CaMV 35S promoter and Cab 5’utr leader sequence

Acetohydroxy acid synthase gene terminator (surB 3’)


Characteristics of Dianthus caryophyllus (Carnation) Expand

Center of Origin Reproduction Toxins Allergenicity

The species is native to the Mediterranean region, including Europe, Asia, and northern Africa.

Carnation flowers are pollinated primarily by butterflies and sometimes by other insects.

The parts of the carnation plants are not thought to be toxic, and the flowers are considered edible.

Occupational exposure to carnation flowers has been associated with allergic reactions in humans.

Donor Organism Characteristics Expand

Latin Name Gene Pathogenicity
Viola hortensis F3’5’H

Viola hortensis is a flowering plant with no human toxicity or allergenicity reported in the literature. There is a report on antithrombin effect caused by the extracts of Viola hortensis.

Petunia X hybrida dfr

Petunia X hybrid is a flowering plant. No toxicity to human or animals are reported. No allergy is linked to petunia exposure. In fact, petunia is considered to be among the safe flower plants to people who are allergic to flower pollens

Nicotiana tabacum surB

Nicotiana tabacum is cultivated tobacco and it is well known for its health effects. Adverse health effects can result from human exposure via inhalation of tobacco smoke, or dermal or oral intake of tobacco products. 

Modification Method Expand

Coming soon.

Characteristics of the Modification Expand

Coming soon.

Environmental Safety Considerations Expand

Coming soon.

Food and/or Feed Safety Considerations Expand

Coming soon.

Links to Further Information Expand

Australia, Office of the Gene Technology Regulator European Food Safety Authority (EFSA) European Union Commission Japan Ministry of Agriculture, Forestry and Fisheries and Ministry of the Environment Malaysian Department of Biosafety Malaysian National Biosafety Board (NBB) The Netherlands Ministry of Infrastructure and the Environment

This record was last modified on Wednesday, December 21, 2016